Research
Principal Investigator:
1. “Clinical Outcomes and Genetic Epidemiology of High
Grade Glioma”
Funding: NSW Cancer Council
Facility: Centre for Minimally Invasive Neurosurgery
Project: The investigators are looking to collaborate between NSW
and WA for biobanking of DNA and potentially tumours, together with
clinical data collection, in collaboration with genetic epidemiologists
in WA who have extensive experience in this area.
Co-investigators: Helen Wheeler, Anna Novak, David Joseph
OPEN
2. “Involvement of the kynurenine pathway in the persistence
of childhood and adult brain tumours”
Funding: Cancer Council
Facility: Bioanalytical Mass Spectrometry Fac, UNSW
Prince of Wales Private Hospital
Project: Attempt to modify the kynurenine pathway in order to boost
the immune response to brain tumor cells
Co-investigators: A/Prof. George Smyth, Dr Karen Cullen, Dr Gilles
Guillemin, Dr Ross Grant
OPEN
3. “Phase III Multinational Clinical Trial on the use
of Transmid for recurrent malignant glioma”
Funding: Xeneca Pharmaceutical
Facility: Prince of Wales Private Hospital
Project: Prospective, randomized, trial of intra-tumoural application
of Transmid. This is a diphtheria toxin bound to transferring, selectively
taken up by tumor cells.
Co-investigator: Prof. Michael Friedlander, PhD, FRCOP
CLOSED
4. "Pathophysiological Mechanisms of Ventriculomegaly"
Funding: CUMG Pilot Study Grant $10,000
Facility: Arkansas Children's Hospital Research Center
Project: To design a canine model of slit-ventricle syndrome
Co-Investigator: Ian Johnston, M.D. F.R.A.C.S.
CLOSED
5. "Endoscopic Laser Management of Experimentally Induced
Aneurysms:
A Potentially New Approach to Basilar Tip Aneurysms"
Funding: NSF-Whittaker Grant $5000
Facility: Arkansas Children's Hospital Research Center
Project: To endoscopically approach artificially created aneurysms
and
obliterate the walls definitively with laser
Co-Investigators: Stephen Flock, Ph.D., Dan Kirse, M.D.
CLOSED
5. "Multi-Center Trial on the Efficacy of Endoscopic
shunt placement"
Funding: Canadian Research Institution $250,000
Facility: Arkansas Children’s Hospital
Project: To assess the efficacy of placing shunts under direct vision
as determined by
shunt revision rates
Co-investigator: John Kestle M.D.
CLOSED
Co-Investigator:
“Microarray analysis of Brain Tumours”
P.I. Bruce Robinson
IN PROGRESS
"Intraventricular Urokinase in the Treatment of Progressive
Post-Hemorrhagic Hydrocephalus"
P.I. Frederick A. Boop, M.D.
CLOSED
"Multi-Center Trial Comparing Delta and Orbis-Sigma Valves in
the Treatment of Hydrocephalus"
P.I. James Drake, M.D.
CLOSED
"Multi-Center Pediatric Head Injury Consortium"
P.I. Bruce Andersen, M.D.
CLOSED
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